Senior Research Associate in San Diego, CA

Job Description:

SUMMARY:

• Client seeks a highly motivated cell and molecular biology contractor to join our Oncology Discovery research team within the Oncogenesis Thematic Research Center (TRC) which specializes in protein homeostasis and targeted protein degradation.
• The successful candidate will work collaboratively to develop and characterize complex patient derived tumor models using 3D bioprinting.
• The ideal candidate should have strong technical skills in mammalian cell culture techniques, basic molecular biology and demonstrate clear verbal and written communication skills.
• Experience in 3D cell culture is also desirable.
• This position is based on-site in San Diego, CA. 

RESPONSIBILITIES:

• Maintain and passage patient derived material to enrich in-house organoid model libraries
• Help develop and implement 3D bioprinting of complex 3D tumor models
• Conduct various fluorescent microscopy assays on 2D cells and 3D cellular models and use image analysis techniques/software to analyze results
• Prepare and analyze histochemistry samples from 3D cellular models, PDX and clinical samples
• Design and execution of experiments in cell biology, molecular biology, and assay development
• Manage cryopreservation of tissues and cell lines
• Maintain an accurate and complete laboratory notebook
• Write laboratory protocols and standard operating procedures
• Assist team members with house-keeping tasks 

REQUIRED SKILLS:

• Mammalian cell culture (3D culture experience is a plus)
• Plate-based assays such as CTG, apoptosis, Incucyte
• Cryopreservation
• Western blotting; WES/JESS ProteinSimple is a plus
• Flow Cytometry
• DNA and RNA extraction and quantification
• Attention to detail and ability to perform delicate manual tasks in a laboratory
• Interest and proven aptitude in learning and applying new laboratory techniques, skills and instrumentation
• Ability to work both independently and as part of a team
• Strong communication skills (able to clearly communicate problems, protocols, and results to colleagues, both in writing and verbally), and ability to keep complete and detailed records
• Drive to seeing projects through to successful completion
• Fluency in the use of Microsoft Word, Excel and PowerPoint; Graphpad Prism & FlowJo is a plus 

EDUCATION: 

• B.S. with a degree relevant experience in biology, chemical biology, chemistry, molecular biology, or a related field

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