Senior Associate Scientist in Cambridge, MA

Job Description:

Seeking a creative and self-motivated Senior Associate Scientist to join team. The candidate will play an essential role in a high-energy RNA and biotherapeutic platform development research laboratory. The candidate will participate in development and innovation of RNA-based therapeutics at a pre-clinical stage. They will be responsible for in-vitro transcription optimization (IVT), purification, and cell-based characterization of new RNA designs using a broad range of molecular biology-based technologies and equipment. The candidate will also contribute to the group wide deliverables.

How You Will Achieve

• Perform efficient IVT & purification protocols for novel RNA therapeutic candidates.
• Perform and support development of molecular biology assays to assess RNA quality and quantification
• Perform functional assessment of RNA in cell culture models
• Routinely provide updates at project meetings and maintain updated records
• Drive technology innovation: design and implement molecular biology strategies to enable small scale analysis of RNAs
• Work closely with multidisciplinary teams including therapeutic discovery teams and R&D project leaders

Qualifications:

Must-Have

• BS with 2-4 years or MS with 0-2 years of relevant experience in Molecular Biology, Biochemistry, Biology, Biomedical Sciences, or a related discipline
• Knowledgeable in nucleic acid biology, and IVT or RNA stability
• Hands-on experience with general molecular biology methods, specifically RNA isolation and assessment techniques such as qPCR, ddPCR, TapeStation or Fragment Analyzer
• Hands-on experience with aseptic cell culture techniques using mammalian cells
• Knowledgeable in preparative and analytical chromatography methods
• Strong written and oral communication skills and ability to work effectively in cross functional teams
• Organized, detail oriented, multi-task, and remain flexible with changing needs
• Must be self-motivated, curious and able to work under strict timeline with limited supervision once trained

Nice-To-Have

• Prior experience in cellular assays (including plate-based assay, gel analysis, FACS, etc).
• Prior experience with purification (using affinity and traditional chromatographic techniques) on AKTA chromatography systems
• Experience in therapeutic drug discovery, gene therapy or RNA therapeutics

Minimum education :

• BS with 2-4 years or MS with 0-2 years of relevant experience in Molecular Biology, Biochemistry, Biology, Biomedical Sciences, or a related discipline

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