- Title: Scientist
- Code: RCI-122123
- RequirementID: 114279
- Location: South San Francisco, CA 94080
- Posted Date: 12/21/2023
- Duration: 6 Months
- Salary ($): 45.61 - 46.03 per Hourly
- Name:Sumit Rawat
- Email: sumit.rawat@rangam.com
- Phone: 908-704-8843 ✖ 232
100% onsite
6 months-Possible extension depends on performance/business need
ADME/DMPK study experience is a must have
Candidates with PhD/PharmD degree (0+ years of experience),MS degree (+3 years of experience), will be considered for Scientist II
General Position Summary/Purpose:
- The Quantitaive Translational ADME Science (QTAS) department is seeking a highly motivated ADME/DMPK Scientist contractor (6 months) to join the In Vitro ADME Science group (Uptake Transporter Center of Excellence).
- The successful candidate will work in collaboration with other team members to characterize the ADME properties of candidate drug molecules.
- QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.
- In this role, you will be a scientist with hands-on experience for routinely managing mammalian cells, hepatocytes-based drug transporter assays to characterize pipeline candidate in a state-of-the art facility.
Key Accountabilities/Core Job Responsibilities:
- Routine mammalian cell culture and preservation in an efficient manner
- Handling and seeding of primary hepatocytes and recombinant cells
- Conducting HT-screening for inhibition potential on uptake transporters
- Conducting in vitro ADME/drug-drug interactions studies
- Analyzing data and maintenance of detailed, accurate and comprehensible study documentations
Qualifications
Education, Qualifications and Experience Requirements (degree, certifications, etc.):
- MS degree (+0 years of experience),
- B.S. (5+ years of experience) -in pharmaceutical sciences, pharmacology, biological chemistry or equivalent in drug metabolism or related discipline with relevant industry experience in drug discovery/development
- Excellent skills and understanding of recombinant/transiently transfected cell lines, culture, seeding, storage is must
- Working experience with hepatocytes, 2D/3D culture
- Hands-on-experience with molecular and cellular biology laboratory techniques
- Working experience with in vitro drug transporters, metabolism is a plus
- Familiarity with enzyme/transporter kinetics, data fitting
- Experience with radioisotope-based assay is a plus
- Knowledge of both biological and physicochemical properties of small molecules that influence ADME
- Experience with use of electronic lab notebook is a plus
- The individual is also expected to be organized, a team player, passionate about drug discovery, and possess effective communication skills
Intake Notes:
Are you open to look at candidates willing to relocate at their own expense? N/A
What are the top 3-5 skills, experience or education required for this position?
- Cell handling (recombinant and primary cell culture, seeding)
- In vitro Transporter assay
- In vitro CYP450 enzyme induction assay
- ADME/DMPK knowledge in drug discovery and development
- Knowledge/experience in drug-drug interactions
What is a nice to have (but not required) skill, experience, education, or certification?
- Working regulatory knowledge
- IND and NDA filing
- Pipeline submission
- Experience with LC-MS/MS is a plus
Daily Work Schedule Expectations Monday to Friday Business hours
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