Scientist in South San Francisco, CA

  • Title: Scientist
  • Code: RCI-122123
  • RequirementID: 114279
  • Location: South San Francisco, CA 94080
  • Posted Date: 12/21/2023
  • Duration: 6 Months
  • Salary ($): 45.61 - 46.03 per Hourly
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  Job Description

100% onsite

6 months-Possible extension depends on performance/business need

ADME/DMPK study experience is a must have

Candidates with PhD/PharmD degree (0+ years of experience),MS degree (+3 years of experience), will be considered for Scientist II

General Position Summary/Purpose:

  • The Quantitaive Translational ADME Science (QTAS) department is seeking a highly motivated ADME/DMPK Scientist contractor (6 months) to join the In Vitro ADME Science group (Uptake Transporter Center of Excellence).
  • The successful candidate will work in collaboration with other team members to characterize the ADME properties of candidate drug molecules.
  • QTAS works very closely with other disciplines (medicinal chemistry, pharmaceutical sciences, pharmacology, toxicology etc.) to conduct preclinical studies, support clinical evaluation and contribute to IND and NDA filings.
  • In this role, you will be a scientist with hands-on experience for routinely managing mammalian cells, hepatocytes-based drug transporter assays to characterize pipeline candidate in a state-of-the art facility.

Key Accountabilities/Core Job Responsibilities:

  • Routine mammalian cell culture and preservation in an efficient manner
  • Handling and seeding of primary hepatocytes and recombinant cells
  • Conducting HT-screening for inhibition potential on uptake transporters
  • Conducting in vitro ADME/drug-drug interactions studies
  • Analyzing data and maintenance of detailed, accurate and comprehensible study documentations

Qualifications

Education, Qualifications and Experience Requirements (degree, certifications, etc.):

  • MS degree (+0 years of experience),
  • B.S. (5+ years of experience) -in pharmaceutical sciences, pharmacology, biological chemistry or equivalent in drug metabolism or related discipline with relevant industry experience in drug discovery/development
  • Excellent skills and understanding of recombinant/transiently  transfected cell lines, culture, seeding, storage is must
  • Working experience with hepatocytes, 2D/3D culture
  • Hands-on-experience with molecular and cellular biology laboratory techniques
  • Working experience with in vitro drug transporters, metabolism is a plus
  • Familiarity with enzyme/transporter kinetics, data fitting
  • Experience with radioisotope-based assay is a plus
  • Knowledge of both biological and physicochemical properties of small molecules that influence ADME
  • Experience with use of electronic lab notebook is a plus
  • The individual is also expected to be organized, a team player, passionate about drug discovery, and possess effective communication skills

Intake Notes:

Are you open to look at candidates willing to relocate at their own expense? N/A

What are the top 3-5 skills, experience or education required for this position?              

  • Cell handling (recombinant and primary cell culture, seeding)
  • In vitro Transporter assay
  • In vitro CYP450 enzyme induction assay
  • ADME/DMPK knowledge in drug discovery and development
  • Knowledge/experience in drug-drug interactions

What is a nice to have (but not required) skill, experience, education, or certification?               

  • Working regulatory knowledge
  • IND and NDA filing
  • Pipeline submission
  • Experience with LC-MS/MS is a plus
In what type of environment would this individual be working (i.e.: Team; Individual; type of office, etc.) ? Lab based Laboratory support hand

Daily Work Schedule Expectations Monday to Friday Business hours

Is overtime offered or required? 
No

Does this position offer the ability to work remotely on a regular basis or is it required to be onsite? no

If remote opportunity exists what are the options (i.e., 1 day remote, 4 days on-site)? N/A

Is Travel expected? If so, will it primarily be domestic or international? No

Is the new hire going to be working with Toxins? No


About Rangam:

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