Scientist in Framingham, MA

M-F 9AM-5PM

Open to candidates willing to relocate at their own expense Possibility of an extension

Must Have/Required Skills:

• 2+ years of pharma/biotech experience
• Hands on experience/coursework/knowledge in mammalian cell culture process development: Experience with mammalian cell cultures (Experience with CHO cells, HEK cells, HeLa cells, CAR-T cells or T-cells, etc), therapeutic molecule production (enzymes, monoclonal antibodies, viral vectors, vaccines or cell therapy) and/or upstream process development (batch, fed-batch or perfusion cultures)
• Coursework/knowledge and preferably past hands-on experience in bioreactor operation (bench scale and/or pilot scale stirred tank bioreactors or wave bioreactors)

Nice to Have/Preferred Skills:

• 3+ years of relevant experience
• Hands on experience/coursework/knowledge in Process Analytical Technology: Experience with sensor technology (spectroscopy, electrochemical, chromatographic or other), PAT applications (process monitoring or process control), or other.
• Hands on experience/coursework/knowledge in Data Analytics: Potential experience with Statistical, Machine Learning or Deep Learning for regression in predictive models.

Experience:

• For MS candidates, we are considering the required years (2-4) as professional work experience only in addition to the degree.
• For PhD candidates, we would be open to consider non-doctoral research in academic settings or temporary industrial placements (Internships/Co-Op) as professional work experience.

Description: 

• As a scientist, the candidate will contribute to the development, characterization, testing and scale-up/down of automated and PAT (Process Analytical Technology) enabled mammalian cell culture process platforms for biotherapeutic manufacturing.
•  The goal of this position is to advance innovation in our manufacturing capabilities by developing robust, scalable, automated, and data-driven cell culture processes for Client’s diverse early and late-stage biologics pipeline.
• The candidate will work in a cross-functional environment and in close collaboration with members from the Cell Culture Development, Process Analytical Technology, Data Sciences, Automation Engineering and Bioanalytics teams at Client 

 Key responsibilities

• Develop, characterize, and test an integrated and automated cell culture process platform and associated process strategies through the integration of sensing technology, data analytics and automation.
• Investigate, design, and independently execute research activities using the aforementioned process platform to improve cell culture process performance (productivity and/or product quality), optimize platform workflows and deepen scientific understanding of cell culture production systems.
• Critically evaluate relevant scientific, technological, and regulatory literature to advance the proposed platform and its impact in our early and late-stage biologics pipeline.
• Lead efforts for industrialization and technology transfer of proposed automated cell culture process platform and associated process strategies within Client.
• Responsible for planning, executing, documenting, and interpreting experimental work and results with appropriate supervision and documentation.
• Author high quality scientific and operational documentation and deliver scientific presentations.

Basic qualifications

• Master’s degree (2-4 years) or PhD degree (0-2 years) in Biotechnology, (Bio)Chemical engineering, Biology, Biochemistry, or a related field.
• Relevant knowledge, coursework and/or hands-on experience in mammalian cell culture process development (e.g., cell biology and biochemistry, cell culture engineering, recombinant protein production, bioreactor engineering, protein product characterization, sterility and aseptic techniques, technology transfer, etc.).
• Strong motivation, curiosity, attention to detail, multitasking ability and active problem-solving and troubleshooting skills.
• Ability to work both independently and in a team-oriented environment with strong project management and communication skills (oral/written).

Preferred Qualifications

• Relevant knowledge, coursework and/or hands-on experience in Process Analytical Technology (PAT), its applications (process monitoring, control, and supervision) and/or in-line/on-line sensing technology (e.g. Spectroscopy, Optical, Enzymatic, Chromatographic sensors, etc.)
• Knowledge, coursework and/or hands-on experience in process data analytics (multivariate, time series and/or signal processing through statistical/machine learning methods).

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