Research Scientist in San Diego, CA

Research Scientist

Location: San Diego, CA. 100% Onsite.

TOP SKILLS:

• Ph.D. in cell biology, immunology, molecular biology, oncology or equivalent field
• Knowledge and experience in using multi-parameter flow cytometry
• Hands-on experience with mammalian cell culture, molecular and cellular technologies (e.g., CRISPR/Cas9 knock-in/out, lentiviral transduction, western blotting, quantitative PCR,) and functional assays (e.g., proliferation, apoptosis, cell cycle) is essential
• Experience in utilizing platforms including IncuCyte, JESS, Flow based cell sorter, ELISA, and MSD in the context of oncology-based drug discovery is a plus

*RESPONSIBILITIES*

• Utilize and develop multiple disease models to design target validation studies and relevant assays in support of SAR, mechanism of action, mechanisms of resistance, biomarker selection, and disease positioning.
• Develop and implement cell-based assays to address both tumor intrinsic cellular biology and immune-based mechanisms of action for potential drug candidates
• Design and conduct essential mechanistic experiments in cell biology, cellular biochemistry, molecular biology, and assay development
• Accurately maintain written reports and present results in an organized and timely manner.
• Communicate effectively, foster teamwork, and contribute to collaborative efforts.
• Strong commitment to quality and demonstrate adaptability.

QUALIFICATIONS*

• Ph.D. in cell biology, immunology, molecular biology, or equivalent field with 0-2 years of post-doc or industry experience, or M.S. degree with 3+ years of experience, or Bachelor’s degree with 5+ years of experience in the biopharmaceutical industry developing and optimizing cell-based assays, preferably in Oncology
• Strong background and experience in cancer research with training in molecular and cell biology
• Extensive experience using multi-parameter flow cytometry in the context of primary immune cell isolation and characterization is required.
• Extensive hands-on experience with mammalian cell culture, molecular and cellular technologies (e.g., CRISPR/Cas9 knock-in/out, lentiviral transduction, western blotting, quantitative PCR,) and functional assays (e.g., proliferation, apoptosis, cell cycle) is essential
• Experience in utilizing platforms including IncuCyte, JESS, Flow based cell sorter, ELISA, and MSD in the context of oncology-based drug discovery is a plus.
• Strong record of high-impact and rigorous science though publication history.
• Proficiency in scientific data analysis programs including GraphPad Prism, FlowJo, Microsoft Excel/Powerpoint, is required
• Capability to deliver high quality data in an organized and timely manner
• Ability to work in a fast-paced dynamic team environment; flexibility to adapt to changes with a positive attitude and independently collaborate across teams, requiring excellent communication skills, both written and verbal, with strong interpersonal skills.

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