Scientist in North Chicago, IL

Location/Site: Lake County, IL - 100% onsite

• LIMS
• Competency with Analyst, Protein Metrics, BioConfirm for data analysis.
• sample extraction
• sample preparation exp
• Small molecules exp will also work
• triple quad LCMS exp needed
• HPLC exp needed
• 3 people in team
• work with biologics larger molecules and some small molecules
• LCMS exp needed
• Some familiarity with large molecules (monoclonal antibodies) exp needed
• Competency with Triple Quad (Sciex) LCMS systems.
• work with serum, plasma, animal serum, monkey serum
• Agilent series and Sciex instruments exp needed
• Analyzing and presenting data
• Masters or bachelors degree with 2-3 yrs exp needed

What are the top 3-5 skills, experience or education required for this position:

• Competency with QTOF (Agilent) and Triple Quad (Sciex) LCMS systems.
• Competency with Analyst, Protein Metrics, BioConfirm for data analysis.
• Experience with sample preparation with biological matrices to enable quantification and characterization studies.
• Familiarity working with large molecules - protein characterization, intact mass, and peptide mapping analysis is highly desired
• A strong understanding of quantitative analysis, including utilization of calibration curves, internal standards, QCs, basic statistics
• Must be able to maintain HPLC and LCMS for routine operations

Client  is seeking a highly motivated scientist to join the Biologics Bioanalysis, Characterization, and Proteomics (BBCP) group in North Chicago, IL.

• This position primarily involves conducting LC/MS-based bioanalysis assays on biologic entities including monoclonal antibodies, antibody drug conjugates (ADC), fusion proteins, etc., to provide essential support for in vitro stability, pre-clinical PK, PK/PD, and Toxicology studies.
• The candidate will be responsible for sample preparation, bioanalytical assay operations, method development, instrument operation and maintenance, data analysis and report generation. This is a 6-month contractor position.

Key tasks and responsibilities:

• Implement bioanalytical methods for quantifying antibodies, ADCs, fusion proteins, peptides, and small molecules using triple quad LC-MS/MS.
• Characterization of antibodies, ADCs, fusion proteins, peptides using intact MS and peptide mapping with high-res MS platforms.
• Routinely assist with sample incubation and preparation for serum stability studies.
• Routinely operate LC-MS and automation instrumentation, including maintenance and troubleshooting.
• Analyze and present data to project teams and stakeholders.
• Utilize and maintain electronic laboratory notebooks for study documentation.
• Support study data entry and archival to RLIMS.

Education and Experience:

Scientist II

• M.S. (2+ years), or B.S. (5+ years) of experience in pharmaceutical or biotechnology industry.
• Highly motivated individual with a strong intellectual and technical background in LC-MS analysis is required. Experience in large-molecule LC-MS bioanalysis is an advantage.
• Direct hands-on experience and/or strong trouble shooting skills in LC-MS bioanalytical laboratory is required. Experience with Triple quad MS (SCIEX), QTOF MS (Agilent) is preferred.
• Utilization of electronic sample management tools and automation systems is a plus.
• High level of attention to detail and proficiency in analytical, organizational, and interpersonal skills.
• Excellent verbal and written communications skills and ability to work independently and excel in a team environment.

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