- Title: Scientist
- Code: RCI-9323
- RequirementID: 122807
- Location: Cambridge, MA 02141
- Posted Date: 11/18/2024
- Duration: 11-12 Months
- Name:Mittal Mandavia
- Email: mittal.mandavia@rangam.com
-
Phone: 908-704-8843 ✖ 245
908-704-8843
Summary
- Client is seeking a highly motivated Scientist I or Scientist II to join the Non-Viral Gene Therapy (NVGT) Team.
- The successful candidate will have hands-on experience in antibody and protein engineering, with a focus on bioconjugation chemistry.
- The candidate will work closely with the LNP formulation team to achieve extrahepatic delivery of LNPs.
Must Have:
- PhD in Chemistry, Biology, Biological Engineering, or a related field
- 1 year of professional work experience (in biotech or pharma)
- Protein and antibody engineering workflows, including primary sequence design, expression, purification, characterization
- Bioconjugate chemistry, also referred to as: antibody conjugate experience ADJ
- Strong analytical bio chem skills
- SDS page, chromatography, HPLC
Preferred Skills:
- Previous experience with: (liquid handler, automated buffers) – biochemical assays (nice to have)
- Computational skills
- Computational and AI/ML approaches for rational protein engineering, including AI 3D structure prediction, homology modeling, antibody/antigen docking, other relevant experience
- L&P Experience
Responsibilities:
- Execute protein conjugation reactions for both screening efforts and developability to enable nanoparticle targeting to specific cells and/or tissues.
- Perform downstream analytical assays such as SDS-PAGE, SEC-HPLC, RP-HPLC, BLI, DSF, CE-SDS and/or flow-cytometry.
- Perform incorporation of targeting antibody into LNPs and execute associated analytical assays, including DLS, zeta potential, nucleic acid content, endotoxin
- Design protein and antibody molecules at the primary sequence level
- Support management of CRO for molecule production
- Closely work with therapeutic area biologists and project teams to design functional experiments and interpret data
- Execute and carefully document experiments using electronic laboratory notebook system and clearly communicate results to team members.
- Plan, execute, and record experiments as guided in a time sensitive manner.
- Assume responsibility for critical reagent sourcing and maintain adequate supply and inventory.
- Author standard operating procedures, study plans and reports and present findings.
- Foster creativity, productivity, execution with a sense of urgency, scientific integrity and accountability. Maintains a collaborative culture.
Requirements:
- PhD in Chemistry, Biology, Biological Engineering, or a related field with a minimum of 1-3 years of relevant industry experience.
- Strong experience with protein and antibody engineering workflows, including primary sequence design, expression, purification, characterization
- Direct experience with site-specific bioconjugate chemistry
- Strong analytical biochemistry experience for protein and antibody engineering
- Proficient in performing structure-function analysis and bioinformatic analysis of antibodies, antigens, and other proteins
- Experience with automation and high throughput platform(s)
- Experience with Biolayer Interferometry or equivalent technique
- Preferred use of computational and AI/ML approaches for rational protein engineering, including AI 3D structure prediction, homology modeling, antibody/antigen docking, other relevant experience
- Preferred familiarity with formulation and analysis of lipid nanoparticles for research use
- Outstanding written and oral communication skills along with the ability to work collaboratively in a team setting.
- Demonstrated knowledge and skills in solving scientific problems, ability to troubleshoot, and willingness to learn.
- Demonstrated ability to independently design, execute, interpret, and present experimental results.
- Flexibility to adapt to rapidly changing priorities and deadlines in a dynamic, fast paced industry and work
Rangam Consultants is a minority, women-owned, disability workforce solutions global organization. We specialize in attracting and retaining talent globally for rewarding careers in IT, Engineering, Scientific, Clinical, Healthcare, Administrative, Finance, Business Management, and many more, while integrating veterans and individuals with disabilities into the workforce. Indeed, we connect career aspirants to relevant job opportunities, whether in the USA, UK, India, or Ireland. Additionally, we offer Location Independent jobs and contract positions across different verticals and industries. Rangam strives to put job seekers first, providing them with free access to search for jobs, post resumes, and research companies. Every day, we connect millions of people to new opportunities. p >