Scientist in Worcester, MA

100% Onsite

• LNP formulation experience is a must have
• Industrial exp preferred
• Hands-on experience with tangential flow filtration (TFF) and sterile filtration.
• Familiar with analytical techniques including but not limited to DLS, zeta potential, SDS-PAGE, ELISA, SEC and RiboGreen assay.
• Polymeric nanoparticles (liposomes) exp will also work

Job Description:  Scientist (Contractor) in Genetic Medicine

• The Biotherapeutics and Genetics Medicine department within Discovery Research is seeking a highly motivated research scientist to join in the newly formed Genetic Medicine (GM) group at Client Bioresearch Center.  Site, based in Worcester, MA, offers a unique setting where GM, Biologics drug discovery, development and manufacturing coexist in one location.
• Our team interacts with multidisciplinary groups across Client focused on developing therapies for Virology, Immunology, Neurology, Ophthalmology and Oncology diseases. 

Duties:

• As an integral member of the GM team this individual will be critical in activities related to mRNA-LNP development, optimization, characterization, including LNP formulation (NanoAssemblr or Jet mixer), size, and surface potential measurement.
• The successful candidate is expected to have hands-on experience with tangential flow filtration (TFF) and sterile filtration.
• As one of the key team members this individual will work with the manager and scientists across different functional groups to discover and develop next generation non-viral genetic medicine.
• You will be relied on as a technical contributor to assess the assigned tasks that involve direct application of your knowledge.
• The candidate will need to have excellent verbal and written skills and the ability to clearly present scientific concepts and results.

Key Responsibilities:

• Help in developing, producing, and characterizing lipid based nucleic acid formulations with targeting moieties for innovative drug products to support multiple internal programs.
• The incumbent should be familiar with analytical techniques including but not limited to DLS, zeta potential, SDS-PAGE, ELISA, SEC and RiboGreen assay.
• Work closely with manager and cross-functional team members on multiple projects simultaneously to collect and analyze data on project basis.
• Under manager’s supervision interpret and summarize experimental data. Present experimental results at meetings as needed.
• Assist in ordering supplies from internal inventory and prepare reagents & other supplies necessary for formulation work.
• Maintain laboratory electronic notebooks (ELN) in compliance with the Client Laboratory Notebook Policy.
• Stay updated and in compliance on all departmental and corporate training.

Key Qualifications:

• BS in Chemistry, Chemical Engineering, Biological Engineering, or a related field with a minimum of 3-5 years of relevant industry experience. MS in biology, chemistry, biomedical engineering, or related field with 0-2 years of nanoparticle design and characterization experience.
• Experience with tangential flow filtration (TFF) and sterile filtration.
• Working knowledge of related tools/software (Prism, FlowJo, FACSDiva etc.).
• Laboratory hands-on experience with nanoparticle formulation and characterization and stability studies.
• Self-motivated, hard-working, detail-oriented, resourceful, and able to work in a fast-paced team environment with demonstrated problem solving and perseverance skills.
• Good Computer skills including word processing, Excel, PowerPoint and relevant scientific software.

Key Competencies:

• Builds strong relationships with peers and cross functionally with partners to enable higher performance.
• Learns fast, grasps the "essence “and can change course quickly where indicated.
• Open to suggestions and experimentation for improvement.
• Strong interpersonal and communication skills with proven ability to work within a team environment.

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