Sr. Research Associate/Scientist, Genome Engineering-NGS, Genomic Medicine Unit in Waltham, MA

Next Generation Sequencing lab – Scientist I.

• Operation of Illumina miSeq and NextSeq instruments.
• Familiarity with NGS data analysis platforms.
• Experience with laboratory automation for sequencing.
• Must be proficient in Excel and lab notebook for record keeping.
• Hamilton automation preferred.

Sr. Research Associate/Scientist, Genome Engineering-NGS, Genomic Medicine Unit

• We are seeking a Sr. Research Associate/Scientist to be part of a team focused on next generation sequencing in genome and cellular engineering in the Genomic Medicine Unit.
• The successful candidate will play a key supporting role in building genome editing technology as an approach for treatment of cancer, rare blood and/or rare genetic diseases.

Specifically, the remit of the candidate will be to:

• Support and lead the implementation of next-generation sequencing techniques to characterize the genotype following genetic engineering.
• Collaborate cross-functionally with team members to process genomic DNA samples to produce sequencing data as efficiently as possible.
• Responsible for applying scientific expertise and judgement to initiate, design and execute experiments in a time sensitive manner.
• Fosters creativity, productivity, execution with a sense of urgency, scientific integrity, and accountability. Maintains a collaborative culture.

Qualifications:

• PhD, no post degree experience required. Or master’s degree plus minimum of 1-2 years of relevant research experience in a biopharmaceutical or academic setting or bachelor’s degree plus a minimum of 2-3 years of experience in a relevant biopharmaceutical or academic setting.
• Degrees must be in biology, biochemistry, chemistry, genetics or a related field.
• Direct next-generation sequencing experience during the above time periods is required.
• Prior experience with the following is preferred:
• Determination of on- and off-target CRISPR-based editing by next generation sequencing.
• Sequencing primer design and library preparation using diverse, state-of-the-art techniques.
• Operation of Illumina miSeq and NextSeq instruments.
• Familiarity with NGS data analysis platforms
• Experience with laboratory automation for sequencing
• Demonstrated ability to independently design, execute, interpret and present experimental results.
• Flexibility to adapt to rapidly changing priorities and deadlines in a dynamic, fast paced industry and work environment.
• Experience in preparing high quality documents including technical reports, presentations, SOPs, experimental protocols and regulatory filings.
• Excellent written and oral communication skills.
• Candidates must be authorized to work in the USA.

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