Oligonucleotide Analytics Scientist in San Diego, CA

• Role is 100% onsite
• Role is Oligonucleotide Analytics and/or Analytical Chemistry
• PhD degree required in a related field
• Performing quality control routines
• Characterizing molecules
• Must have at least 1 year of industry experience with PhD

Top Skills needed:

• Oligonucleotide analytics
• Analytical chemistry
• siRNA experience a MUST
• LCMS experience

Key Responsibilities:

• 30% Operating LC-MS systems to perform in-process and final QC of various scales of highly modified oligonucleotides, including siRNA and ASO, to support both discovery portfolio and pre-portfolio projects
• 20% Optimize methods and improve analytical capabilities for novel Oligonucleotide synthesis
• 10% Analyze and optimize methods in a project-specific way (i.e. GalNAc vs Cholesterol vs C16) by denaturing and non-denaturing HPLC methods. In addition, phosphoramidites or lipids by HPLC and LCMS.
• 20% Establish and automate high throughput analytical capabilities and coordinate those efforts with higher synthesis throughput.
• 5% Analyze oligonucleotides by HPLC-SEC, RP-IP and Ion-Exchange Chromatography.
• Continue optimizing siRNAs using best-in class analytical chemistry methodologies such as different column matrixes for optimal siRNA characterization
• Support integrity confirmation requests (such as concentration) by assay development and biology teams
• 3% Conduct QC for lipid nanoparticle (LNP) formulations of mRNA
• 5% Ensure the supply of laboratory consumables and reagents are in stock as needed
• Maintain a high level of productivity in the laboratory setting.
• 2% Present data and reports on project status at individual, group, and departmental meetings.

Rangam Consultants is a minority, women-owned, disability workforce solutions global organization. We specialize in attracting and retaining talent globally for rewarding careers in IT, Engineering, Scientific, Clinical, Healthcare, Administrative, Finance, Business Management, and many more, while integrating veterans and individuals with disabilities into the workforce. Indeed, we connect career aspirants to relevant job opportunities, whether in the USA, UK, India, or Ireland. Additionally, we offer Flexible Work Arrangement jobs and contract positions across different verticals and industries.
Rangam strives to put job seekers first, providing them with free access to search for jobs, post resumes, and research companies. Every day, we connect millions of people to new opportunities.